ALCOHOL INHIBITS THE METABOLISM OF DIMETHYL FUMARATE TO THE ACTIVE METABOLITE RESPONSIBLE FOR DECREASING RELAPSE FREQUENCY IN THE TREATMENT OF MULTIPLE SCLEROSIS.

Dimethyl fumarate (DMF) is a first-line prodrug for the treatment of relapsing-remitting multiple sclerosis (RRMS) that is completely metabolized to monomethyl fumarate (MMF), the active metabolite, before reaching the systemic circulation.Its metabolism has been proposed to be due to ubiquitous esterases in the intestines and other tissues, but th

The article traces the history of Ezra Pound’s engagement with Fascist politics and its contemporary influence on the far-right in America, Britain and Italy.It seeks to Baggies explore a Baby Tee political legacy of Pound’s, which is sometimes strangely at odds with his poetic legacy but on other occasions, informs and coalesces into the latte

Meir Nitzan,1 Ayal Romem,2 Robert Koppel31Department of Physics/Electro-Optics, Jerusalem College of Technology, Jerusalem, Israel; 2Pulmonary Institute, Shaare Zedek Medical Center, Jerusalem, Israel; 3Neonatal/Perinatal Medicine, Cohen Children's Medical Center of New York/North Shore-LIJ Health System, New Tank Hyde Park, NY, United StatesAb